硕士研究生指导教师-顾雪锋

发布者:董尹发布时间:2019-04-18浏览次数:3435

姓名

顾雪锋

 

工作单位

上海健康医学院

职称

副教授

导师资格

硕士研究生指导教师

学科专业

肿瘤分子生物学及大数据生物信息学

联系方式

电话:18602197911

E-mailguxf@sumhs.edu.cn

一、个人简介

硕导,哈尔滨工业大学本科和硕士,韩国首尔大学博士,主要从事恶性肿瘤的发生发展及侵袭转移,医学大数据分析挖掘,生物信息学等相关研究。主持过黑龙江省科技攻关项目,哈尔滨市青年科学基金,广东省自然科学基金项目,上海市科技支撑项目,参与过国家863重大专项计划,国自然等项目研究,连续两年获得广东省扬帆计划人才资助,获得发明专利6项,发表SCI论文20多篇,其中发表于神经肿瘤学权威杂志Neuro-OncologyIF=10.091的工作被他引34次。

XUEFENG GU received the B.S. degree and the master’s degree in   biotechnology from the Harbin Institute of Technology (HIT), China, in 2001   and 2004, and the Ph.D. degree in dental science from Seoul National   University (SNU), South Korea, in 2009. He is currently a researcher with the   Shanghai Key Laboratory of Molecular Imaging, Collaborative Research Center,   Shanghai University of Medicine and Health Sciences (SUMHS), China. His   current research interests include the role of the different signaling   pathways in cancer, bioinformatics in biology and medicine and some important   tumor-related genes in occurrence and development of malignant tumors.

二、主要学习与工作经历

教育背景:

2006/03-2009/06,韩国首尔大学,分子生物学,博士,导师:李宗镐

2001/09-2004/01,哈尔滨工业大学,分子生物学,硕士,导师:朱大海

1997/09-2001/07,哈尔滨工业大学,生命科学与工程系,学士

工作经历:

2017/11-至今,上海健康医学院,上海市分子影像重点实验室,讲师,硕导

2016/01-2017/10,广东医科大学,神经病学研究所,助理研究员

  2013/01-2015/12,广东医科大学,神经病学研究所,博士后

三、主要科研工作与成绩

论文发表:

(1) WH Huang*, XF Gu*,   YY Wang*, YH Bi, Y Yang, GQ Wan, NH Chen, KS Li. Effects of the   co-administration of MK-801 and clozapine on MiRNA expression profiles in   rats. Basic Clin Pharmacol Toxicol. 2021 Mar 3. doi:   10.1111/bcpt.13576. 

(2) YJ Zheng , GQ Wan, B   Yang, XF Gu#, JR Lin#. Cardioprotective   Natural Compound Pinocembrin Attenuates Acute Ischemic Myocardial Injury via   Enhancing Glycolysis. Oxid Med Cell Longev. 2020 Oct 15;2020:  doi: 10.1155/2020/4850328.

(3) DS Liu, XJ Zuo, P   Zhang, R Zhao, DL Lai, KJ Chen, YR Han, GQ Wan, YJ Zheng# ,   CL Lu#, XF Gu#. The Novel Regulatory Role   of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics   Analysis.Comput Math Methods Med. vol. 2021.   https://doi.org/10.1155/2021/5526179

(4) XF Gu*, GQ Wan*, Y Yang*, YH Liu, XT   Yang, YJ Zheng, LY Jiang, P Zhang, DS Liu, WM Zhao, G Huang, CL Lu. SLFN5   influences proliferation and apoptosis by upregulating PTEN transcription via   ZEB1 and inhibits the purine metabolic pathway in breast cancer. Am J   Cancer Res. 2020 Sep 1;10(9):2832-2850.

(5) Q Han, Y Fu, JM Le, A   Pilot, S Cheng, PQ Chen, HL Wu, GQ Wan#, XF Gu#.   Electroacupuncture   may alleviate behavioral defects via modulation of gut microbiota in a mouse   model of Parkinson's disease. Acupunct Med. 2021 Feb 8;

(6) GQ Wan*, J Zhu*, XF   Gu*, Y Yang, YH Liu, ZZ Wang, YX Zhao, HL Wu,G Huang, CL Lu. Human   Schlafen 5 regulates reversible epithelial and mesenchymal transitions in   breast cancer by suppression of ZEB1 transcription. Br J Cancer. 2020   Jun 3.  doi: 10.1038/s41416-020-0873-z.

(7) XF Gu*, DY Jiang*, Y Yang, P Zhang, GQ   Wan, WX Gu, JF ShiLY Jiang, B Chen,YJ   Zheng, DS Liu ,SF Guo, CL Lu. Construction and Comprehensive Analysis of   Dysregulated Long Noncoding RNA-Associated Competing Endogenous RNA Network   in Moyamoya Disease. Comput Math Methods Med. 2020 June 13, Doi:10.1155/2020/2018214

(8) Shen Y, Jia Y, Li Y, Gu   X, Wan G, Zhang P, Zhang Y, Jiang L. Genetic   determinants of gestational diabetes   mellitus: a case-control study in two independent populations. Acta   Diabetol. 2020 Feb 29. doi: 10.1007/s00592-020-01485-w. [Epub ahead of   print];

(9) FJ Hao, JF Shi, YY   Chen, XF Gu#, D Ma#. Integrated analysis of a   noncoding RNAassociated competing endogenous RNA network in non-alcoholic   fatty liver disease. IEEE Access PP(99):1-1May 2020DOI 10.1109 /ACCESS. 2020.2992109

(10) Zhang P*, Wang J*,   Zhang X*, Wang X, Jiang L, Gu X#. Identification of  AIDS-Associated Kaposi Sarcoma: A Functional   Genomics Approach. Front Genet. 2020 Jan 24;10:1376. doi:   10.3389/fgene.2019.01376. eCollection 2019.

(11) Gu X*, Wan G*, Chen N*, Li J,   Chen B, Tang Y, Gu W, Jin C, Meng J, Zhang P,  Liu L, Yang Z, Lu C. DGKζ Plays Crucial   Roles in the Proliferation and Tumorigenicity of Human glioblastoma. Int J   Biol Sci. 2019; 15(9): 1872–1881.

(12) Wan G, Liu Y, Zhu J,   Guo L, Li C, Yang Y, Gu X, Deng LL, Lu C. SLFN5 suppresses cancer cell   migration and invasion by inhibiting MT1-MMP expression via   AKT/GSK-3β/β-catenin pathway. Cell Signal. 2019 Jul;59:1-12. Epub 2019   Mar 4.

(13) 韩秋琴,万国庆,顾雪锋#,基于16S rRNA基因测序探讨鱼藤酮诱导的帕金森病模型小鼠体内肠道微生物的变化,解剖学报2020.08, 508-513.

(14) 岑学程,高力扬,陈兵,杨帆,龙霄翱,顾雪锋,李锦宏. GSK3对人脑胶质瘤增殖的影响及基因表达谱富集分析《广东医科大学学报》 2018.01.

(15) 李锦宏,陈兵,顾雪锋#,马国达,杨帆,高力扬,廖壮槟,林亨,龙霄翱. 乙二醛酶1在脑胶质瘤组织中的表达《广东医学院学报》 2016.05.

(16) 黄文辉,顾雪锋,李克深. 微小RNA在神经退行性疾病发病机制中作用的研究进展《山东医药》 2016.41.

(17)    Xuefeng Gu*, Ce Wang*, Xuefeng   Wang*, Guoda Ma, You Li, Lili Cui, Yanyan Chen, Bin Zhao#,   Keshen Li#, Efficient inhibition of human glioma   development by RNA interference-mediated silencing of PAK5,  Int J Biol Sci., 2015, 11(2): 230-7

(18) Xuefeng Gu*, Xuefeng Wang*, Hong   Xiao*, Guoda Ma, Lili Cui, You Li, Haihong Zhou, Wandong Liang, Bin Zhao#,Keshen   Li#, Silencing of R-Spondin1 increases radiosensitivity of   glioma cells, Oncotarget, 2015, 6(12): 9756-65

(14) Xuefeng Gu*, Lifen Yao*, Guoda Ma, Lili Cui, You Li, Wandong Liang, Bin Zhao#,   Keshen Li#, TCTP promotes glioma cell proliferation in vitro and   in vivo via enhanced β-catenin/TCF-4 transcription, Neuro-Oncology,   2014, 16(2): 217-27

(15) Zheping FANG*,   Beige Jiang*, Xuefeng Gu*, Bin   Zhao, RuiLiang Ge#, Fabiao Zhang#, P21-activated kinase   5 plays essential roles in the proliferation and tumorigenicity of human   hepatocellular carcinoma, Acta Pharmacol Sin, 2014, 35(1): 82-8

(16) Guoda Ma*, Haiyang Wang* , Xuefeng Gu, Wei Li, Xingli Zhang,   Lili Cui, You Li, Yong Zhang, Bin Zhao#, Keshen Li#,   CARP, a Myostatin-down regulated gene in CFM cells, is a novel essential   positive regulator of myogenesis,  Int J Biol Sci, 2014, 10(3): 309-20

(17) You Li*, Cheng   Yang*, Guoda Ma, Lili Cui, Xuefeng Gu,   Yanyan Chen, Bin Zhao, Haiyang Wang#, Li K#,   Analysis of ADAM17 polymorphisms and susceptibility to sporadic abdominal   aortic aneurysm, Cell Physiol Biochem, 2014, 33(5): 1426-38

(18) You Li*, Cheng Yang*,   Guoda Ma, Xuefeng Gu, Min Chen,   Yanyan Chen, Bin Zhao, Lili Cui #, Keshen Li #,   Association of Polymorphisms of the Receptor for Advanced Glycation End   Products Gene with COPD in the Chinese Population, DNA Cell Biol,   2014, 33(4): 1-8

(19) Hongjiang He, Xuefeng Gu, Wanhai Xu, Dejun   Yang, Xiaomin Wang ,Yu Su#, Krüppel-like factor 8   is a novel androgen receptor co-activator in human prostate cancer, Acta   Pharmacol Sin, 2013, 34(2): 282-8

(20) Wang HB, Wang QG, Zhang XY, Gu   XF, Wang N, Wu SB, Li H. Microarray analysis of genes differentially   expressed in the liver of lean and fat chickens. Animal (2010), 4:4,   pp 513–522

(21) XueFeng Gu*, Jongho Lee, Sangbae Yoo,   Youngwha Moon, Jeongwon Jahng#, Intra-oral pre-treatment   with capsaicin increases consumption of sweet solutions in rats, Nutritional   Neuroscience, 2009, 12(4): 149-154

(22) V Ryu, J-H Lee, SB Yoo, XF   Gu, YW Moon and JW Jahng#.Sustained hyperphagia in   adolescent rats that experienced neonatal maternal separation. Int J Obes   (Lond). 2008;32(9):1355-62.

(23) KS Li, DM Dong, LF Yao, DW   Dai, XF Gu, L Guo#. Identification of STC1 as an   beta-amyloid activated gene in human brain microvascular endothelial cells   using cDNA microarray.Biochem Biophys Res Commun. 2008;376(2):399-40

(24) KS Li, DW Dai, LF Yao,   XF Gu, K Luan,WJ Tian, YS Zhao, BY Wang#. Association   between the macrophage inflammatory protein-l alpha gene polymorphism and   Alzheimer's disease in the Chinese population. Neurosci Lett. 2008;433(2):125-8

(25) Keshen Li, Xuefeng Gu, Ping Li, Yong Zhang, Yashuang Zhao, Zhenjiang Yao,   Naiqiang Qu, Binyou Wang#,   Effect of pseudolaric acid B on gastric cancer cells: Inhibition of   proliferation and induction of apoptosis, World Journal of   Gastroenterology, 2005, 11(48): 7555-7559

(26) 高兴春,顾雪峰,韩俊,基于电子克隆方法获得鸡MIBP全长cDNA,生物信息学,2005,(02):58-61

会议论文:

(1) Xuefeng   Gu, Vitaly Ryu, Seoul Lee, Jong Ho Lee, Jeong Won Jahng. Repeated   exposure to capsaicin increases sucrose drinking and gene expression of sweet   taste receptors in rats.Appetite (2006) 46; 357

(2) Xuefeng   Gu, Jong-Ho Lee, Ke-Shen Li, JW Jahng. Gene Expression Profiles of As2O3-Treated   Cervical Cancer Hela Cells.Proceeding of the 5th International Forum on   Post-Genome Technologies. 2007;5(1)357-360. (ISTP, UT ISIP:000251162700127).

授权发明专利:

PBX1基因的用途及其相关药物,2016.01.13,中国,ZL201210005699.1

CIT基因的用途及其相关药,2019.03.26,中国,ZL201210162600.9

CUL4B基因的用途及其相关药物,2018.08.07,中国,ZL201210313850.8

IFITM3基因的用途及其相关药物,2018.03.27, 中国,ZL201210314142.6

STIM1基因的用途及其相关药物,2015.07.08, 中国,ZL201110425916.8

NLK基因相关的用途及其相关药物,2015.04.29, 中国,ZL201110440594.4

课题与项目:

1. 广东省自然科学基金项目,2016A030313680,翻译控制肿瘤蛋白TCTP对胶

质瘤细胞干性的影响及机制研究,2016/07-2019/0610万元,已结题,主持;

2. 2016年广东省扬帆计划,2016年,12万元;

3. 2015年广东省扬帆计划,2015年,12万元;

4.  上海健康医学院协同创新重点专项SLFN5在肿瘤转移中的作用及其分子网络调,控机制,2018/07-2020/07100万元,参加;

5. 上海市委办局科研项目,研究外周血lncRNA与膝骨关节炎的关联研究,2019/01-2021/1210万,参加;

6. 产学研横向课题,NK细胞来源外泌体靶向治疗脑胶质瘤的应用研究,2018/09-2021/0815万,主持;

7. 教委教师发展工程,脑胶质瘤细胞来源外泌体的蛋白质组学分析,2020/04-       2020/125万,主持;

8. 优秀青教计划-市教委,思政教育在高等医学院校生物化学专业课教学中的有机融入,2019/06-2021/066万,主持;

9. 校级种子基金,PAK5通过AKT途径促进脑胶质瘤发生发展的机制研究,2018/01-2019/125万,主持;

10. 国家自然科学基金项目,81801833tRNA羧甲基修饰酶Elongator在肺腺癌有丝分裂中的作用与分子机制研究2019/01-2021/1221万元,参加;

四、主要社会学术团体兼职

神经肿瘤学会SNO会员;

SSIB会员;

AOCN会员;

上海市浦东新区周浦医院双聘人才;健康医苗创新创业指导教师;

Frontiers in Genetics, Biomed Research International, Chronobiology   InternationalCurrent   BioinformaticsSCI杂志论文评审专家

五、主要研究方向

1.大数据分析及生物信息学方向:偏工科方向,面对大量的生物及疾病相关数据累积,从全局和系统水平研究和分析生物学或者医学问题,它是当今自然科学交叉的重大前沿领域之一。毕业方向开阔:药企,各类生物医学相关高科技企业,大数据分析需求企业,高校,银行,保险,医院,或继续深造等;

2.肿瘤分子生物学:偏理学方向,基于大数据分析后的基因功能验证,分子机制研究,药物靶点筛选;毕业方向:生物企业,医院,或继续深造等;

3.产品研发:偏应用方向,生物功能蛋白的表达纯化;中医药保健品的应用研发;医疗器械的应用研发;微信小程序的应用研发;

六、有合作项目的企业、医院、研究所等,以及合作项目名称

1.上海市周浦医院:生物信息学的临床疾病及相关大数据分析应用

2.上海锐赛生物技术有限公司:NK细胞来源外泌体靶向治疗脑胶质瘤的应用研究

3.上海万乘基因:新一代测序技术的应用研究及数据分析

4.中国移动上海移动通迅公司:移动大数据与疾病相关大数据的整合技术探讨

5.上海瑞金医院:单细胞测序在甲状腺癌的应用研究